Ingredient name record

Hyaluronic Acid

Evidence at a glance

4official function labelsIngredient context 3selected human studiesNot a full review

0selected legal receiptsNot a compliance verdict

248product recordsRecorded occurrences

Evidence coverage, not an efficacy or safety score.

Identity & coverage details

Official CosIng inventory context recorded; chemical identity and the complete current regulatory profile remain unverified; selected human studies available.

Recorded presence is not a safety rating, recommended dose or benefit claim.

Identity and formulation context

Names are indexed using case and whitespace normalization. Botanical, chemical and marketing identities have not been independently equated.

Molecular weight and cream base were part of the intervention. Ingredient presence alone does not identify either. These added studies concern a microneedle delivery system or a multi-ingredient serum-and-cream combination. They do not replace the existing topical molecular-weight study and cannot establish equivalence to sodium salts, hydrolyzed forms, crosspolymers or any finished Treatfolio product.

Functions listed by CosIng

ANTISTATICHUMECTANTMOISTURISINGSKIN CONDITIONING

Inventory functions describe the ingredient entry, not a finished product’s effects.

How this inventory match is used

The European Commission’s CosIng inventory is informational. An entry is not permission to use an ingredient or a safety assessment. Listed functions describe the inventory entry; they do not establish a finished product’s effects. The match uses the exact ingredient name, with case and whitespace normalization.

HYALURONIC ACID · Inventory identifiers

Inventory record: 34315 · Active
CAS identifiers in this entry: 9004-61-9
EC identifiers in this entry: 232-678-0

Checked 2026-10-02 · Read the official CosIng entry

Human study context

Primary publications checked 2026-10-02. These are selected studies, not a systematic review, safety rating or instructions for using a product.

Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment

2011 · Original abstract reviewed

Material tested: Hyaluronan at specified molecular weights in 0.1% creams
Study design: Randomized comparison around opposite eyes against a vehicle cream.
Participants: 76 women, ages 30–60, with visible wrinkles around the eyes.
Concentration and schedule in the study: 0.1% hyaluronan creams with molecular weights of 50, 130, 300, 800 or 2,000 kDa, twice daily for 60 days.
What the authors reported: The authors reported improved hydration and elasticity with the tested creams. Wrinkle-depth improvement versus vehicle was reported for the 50 and 130 kDa groups at day 60.

What this does not establish

One periocular formulation study; findings do not establish that all molecular weights give the same outcome.
An INCI label does not disclose molecular weight or the tested cream base.
Results are not assigned to sodium hyaluronate, hydrolyzed derivatives or crosspolymers by alias.

Read the original publication

Hyaluronic acid microneedle patch for the improvement of crow's feet wrinkles

2017 · Original abstract reviewed

Material tested: Hyaluronic-acid microneedle patches versus an essence described as containing the same active ingredients.
Study design: Randomized split-face study with blinded dermatologist assessments.
Participants: 34 Korean women with mild-to-moderate crow's-feet wrinkles.
Concentration and schedule in the study: Patch or essence twice weekly for eight weeks, with assessments at weeks two, four and eight.
What the authors reported: Measured wrinkles and elasticity improved on both sides; the patch side improved more at week eight. No irritation was observed in the specified patch irritation tests.

What this does not establish

This compares delivery systems, not hyaluronic acid against vehicle.
Concentration, molecular weight and complete ingredient identities are absent from the abstract.
Some authors were affiliated with Hugel R&D. Limited irritation tests do not establish universal safety.

Read the original publication

A Prospective Double-blind, Placebo-controlled Clinical Trial Evaluating the Efficacy of a Novel Combination of Hyaluronic Acid Serum and Antioxidant Cream for Rejuvenation of the Aging Neck

2020 · Original abstract reviewed

Material tested: Fractionated hyaluronic-acid serum with peptides and antioxidants, plus a cream; compared with serum and cream vehicles.
Study design: Prospective, randomized, double-blind, placebo-controlled trial.
Participants: 31 healthy participants with moderate-to-severe neck wrinkling: 20 active-system and 11 vehicle.
Concentration and schedule in the study: Two months on the neck; application frequency, hyaluronic-acid concentration and molecular weight are not specified in the abstract.
What the authors reported: Both active and vehicle groups improved in several skin-appearance measures. Histology from one active-treatment sample showed collagen and elastic-fiber changes.

What this does not establish

The abstract does not establish between-group superiority; both groups improved.
Multiple ingredients and two products prevent isolation of hyaluronic acid. One histology sample is limited.
Topix Pharmaceuticals funded the study.

Read the original publication

Still unverified

This is a partial literature record, not a systematic review.
These study preparations have not been matched to any Treatfolio product, batch or concentration.
This is a selected partial literature record, not a systematic review or a complete scientific profile.
Cosmetic functions and jurisdiction-specific restrictions are not established by these research abstracts.
Study preparations have not been matched to any Treatfolio product, batch, market or concentration.
Chemical identity, the complete current regulatory profile and finished-product effects remain unverified.